EGF receptor trafficking: consequences for signaling and cancer

EGF receptor trafficking: consequences for signaling and cancer

Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the cell surface. • Endocytosis can have positive and negative effects on signaling and tumorigenesis. • EGFR traffic promoted by antineoplastic the...

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Veröffentlicht in:Trends in cell biology 2014-01, Vol.24 (1), p.26-34
Hauptverfasser: Tomas, Alejandra, Futter, Clare E, Eden, Emily R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
antineoplastic therapy
Endocytosis
epidermal growth factor receptor (EGFR)
ErbB Receptors - antagonists & inhibitors
ErbB Receptors - genetics
ErbB Receptors - metabolism
GRB2 Adaptor Protein - metabolism
Humans
Multivesicular Bodies - metabolism
Mutation
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
oncogenes
Pathology
Protein Transport
Proteolysis
Review
Signal Transduction
trafficking
Ubiquitination
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Beschreibung
Zusammenfassung:Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the cell surface. • Endocytosis can have positive and negative effects on signaling and tumorigenesis. • EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2013.11.002