EGF receptor trafficking: consequences for signaling and cancer
Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the cell surface. • Endocytosis can have positive and negative effects on signaling and tumorigenesis. • EGFR traffic promoted by antineoplastic the...
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| Veröffentlicht in: | Trends in cell biology 2014-01, Vol.24 (1), p.26-34 |
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| container_title | Trends in cell biology |
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| creator | Tomas, Alejandra Futter, Clare E Eden, Emily R |
| description | Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the cell surface. • Endocytosis can have positive and negative effects on signaling and tumorigenesis. • EGFR traffic promoted by antineoplastic therapy is important in tumor resistance. |
| doi_str_mv | 10.1016/j.tcb.2013.11.002 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0962-8924 |
| ispartof | Trends in cell biology, 2014-01, Vol.24 (1), p.26-34 |
| issn | 0962-8924 1879-3088 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Collection |
| subjects | Animals Antineoplastic Agents - pharmacology antineoplastic therapy Endocytosis epidermal growth factor receptor (EGFR) ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism GRB2 Adaptor Protein - metabolism Humans Multivesicular Bodies - metabolism Mutation Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology oncogenes Pathology Protein Transport Proteolysis Review Signal Transduction trafficking Ubiquitination |
| title | EGF receptor trafficking: consequences for signaling and cancer |
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