Oxime Cross-Linked Injectable Hydrogels for Catheter Delivery

Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross‐linked hydrogel system is demonstrated. The syst...

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Veröffentlicht in:	Advanced materials (Weinheim) 2013-06, Vol.25 (21), p.2937-2942
Hauptverfasser:	Grover, Gregory N., Braden, Rebecca L., Christman, Karen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemistry Body temperature Catheters Crosslinking Gelation Heating Hydrogels Hydrogels - chemistry injectable hydrogels Injections oxime cross-linking Oximes Oximes - chemistry Polyethylene Glycols - chemistry
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Beschreibung
Zusammenfassung:	Catheter delivery of therapeutic materials is important for developing minimally invasive treatment approaches. However, the majority of injectable materials gel rapidly upon mixing and/or heating to body temperature. The application of an oxime cross‐linked hydrogel system is demonstrated. The system has a broad range of tunable gelation rates, is capable of injection through a catheter, and exhibits rapid gelation upon injection into tissue.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201205234