Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts

Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A ma...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2012-03, Vol.66 (3), p.479-485
Hauptverfasser:	Murrell, Dedee F., MA, BMBCh, MD, FACD, Daniel, Benjamin S., MBBS, Joly, Pascal, MD, PhD, Borradori, Luca, MD, Amagai, Masayuki, MD, PhD, Hashimoto, Takashi, MD, PhD, Caux, Frédéric, MD, PhD, Marinovic, Branka, MD, PhD, Sinha, Animesh A., MD, PhD, Hertl, Michael, MD, Bernard, Philippe, MD, PhD, Sirois, David, DMD, PhD, Cianchini, Giuseppe, MD, Fairley, Janet A., MD, Jonkman, Marcel F., MD, PhD, Pandya, Amit G., MD, Rubenstein, David, MD, PhD, Zillikens, Detlef, MD, Payne, Aimee S., MD, PhD, Woodley, David, MD, Zambruno, Giovanna, MD, Aoki, Valeria, MD, PhD, Pincelli, Carlo, MD, Diaz, Luis, MD, Hall, Russell P., MD, Meurer, Michael, MD, PhD, Mascaro, Jose M., MD, Schmidt, Enno, MD, Shimizu, Hiroshi, MD, PhD, Zone, John, MD, Swerlick, Robert, MD, Mimouni, Daniel, MD, Culton, Donna, MD, Lipozencic, Jasna, MD, PhD, Bince, Benjamin, MD, Grando, Sergei A., MD, PhD, DSc, Bystryn, Jean-Claude, MD, Werth, Victoria P., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bullous diseases of the skin bullous pemphigoid Consensus definitions Dermatology Dermatology - standards Humans Medical sciences Outcome Assessment (Health Care) outcome measures Pemphigoid, Bullous - diagnosis Severity of Illness Index severity score
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Zusammenfassung:	Our scientific knowledge of bullous pemphigoid (BP) has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in BP. A major obstacle in sharing multicenter-based evidences for therapeutic efforts is the lack of generally accepted definitions for the clinical evaluation of patients with BP. Common terms and end points of BP are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. These recommendations from the International Pemphigoid Committee represent 2 years of collaborative efforts to attain mutually acceptable common definitions for BP and proposes a disease extent score, the BP Disease Area Index. These items should assist in the development of consistent reporting of outcomes in future BP reports and studies.
ISSN:	0190-9622 1097-6787
DOI:	10.1016/j.jaad.2011.06.032