Generating rats with conditional alleles using CRISPR/Cas9

Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases (ZFNs) [1-2], transcription activator-like effector nucleases (TALENs) [3] and the C...

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Veröffentlicht in:Cell research 2014-01, Vol.24 (1), p.122-125
Hauptverfasser: Ma, Yuanwu, Zhang, Xu, Shen, Bin, Lu, Yingdong, Chen, Wei, Ma, Jing, Bai, Lin, Huang, Xingxu, Zhang, Lianfeng
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container_end_page 125
container_issue 1
container_start_page 122
container_title Cell research
container_volume 24
creator Ma, Yuanwu
Zhang, Xu
Shen, Bin
Lu, Yingdong
Chen, Wei
Ma, Jing
Bai, Lin
Huang, Xingxu
Zhang, Lianfeng
description Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases (ZFNs) [1-2], transcription activator-like effector nucleases (TALENs) [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats (CRISPR)/CRISPR-associated 9 (Cas9) system [4-5],
doi_str_mv 10.1038/cr.2013.157
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Several genome-editing technologies, such as zinc-finger nucleases (ZFNs) [1-2], transcription activator-like effector nucleases (TALENs) [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats (CRISPR)/CRISPR-associated 9 (Cas9) system [4-5],</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2013.157</identifier><identifier>PMID: 24296780</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/1513 ; 631/1647/334/1874/486 ; Alleles ; Animals ; Biomedical and Life Sciences ; Cell Biology ; Clustered Regularly Interspaced Short Palindromic Repeats - genetics ; CRISPR-Associated Proteins - genetics ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA Methyltransferase 3A ; DNA Methyltransferase 3B ; Gene Knockout Techniques ; Letter to the Editor ; Life Sciences ; Rats ; Rats, Transgenic ; 基因组 ; 大鼠 ; 实验模型 ; 小鼠模型 ; 核酸酶 ; 编辑技术 ; 药理学 ; 转录激活</subject><ispartof>Cell research, 2014-01, Vol.24 (1), p.122-125</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><rights>Copyright © 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-b017239fbe17be9d8059a513d15e5f6106311e03457445cf7e239859e17acff33</citedby><cites>FETCH-LOGICAL-c473t-b017239fbe17be9d8059a513d15e5f6106311e03457445cf7e239859e17acff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879705/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879705/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24296780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yuanwu</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Shen, Bin</creatorcontrib><creatorcontrib>Lu, Yingdong</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Bai, Lin</creatorcontrib><creatorcontrib>Huang, Xingxu</creatorcontrib><creatorcontrib>Zhang, Lianfeng</creatorcontrib><title>Generating rats with conditional alleles using CRISPR/Cas9</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Research</addtitle><description>Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. 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subjects 631/1647/1513
631/1647/334/1874/486
Alleles
Animals
Biomedical and Life Sciences
Cell Biology
Clustered Regularly Interspaced Short Palindromic Repeats - genetics
CRISPR-Associated Proteins - genetics
DNA (Cytosine-5-)-Methyltransferase 1
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA Methyltransferase 3A
DNA Methyltransferase 3B
Gene Knockout Techniques
Letter to the Editor
Life Sciences
Rats
Rats, Transgenic
基因组
大鼠
实验模型
小鼠模型
核酸酶
编辑技术
药理学
转录激活
title Generating rats with conditional alleles using CRISPR/Cas9
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