Generating rats with conditional alleles using CRISPR/Cas9
Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the C...
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| Veröffentlicht in: | Cell research 2014-01, Vol.24 (1), p.122-125 |
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| creator | Ma, Yuanwu Zhang, Xu Shen, Bin Lu, Yingdong Chen, Wei Ma, Jing Bai, Lin Huang, Xingxu Zhang, Lianfeng |
| description | Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats （CRISPR）/CRISPR-associated 9 （Cas9） system [4-5], |
| doi_str_mv | 10.1038/cr.2013.157 |
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Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats （CRISPR）/CRISPR-associated 9 （Cas9） system [4-5],</description><identifier>ISSN: 1001-0602</identifier><identifier>EISSN: 1748-7838</identifier><identifier>DOI: 10.1038/cr.2013.157</identifier><identifier>PMID: 24296780</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/1513 ; 631/1647/334/1874/486 ; Alleles ; Animals ; Biomedical and Life Sciences ; Cell Biology ; Clustered Regularly Interspaced Short Palindromic Repeats - genetics ; CRISPR-Associated Proteins - genetics ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA Methyltransferase 3A ; DNA Methyltransferase 3B ; Gene Knockout Techniques ; Letter to the Editor ; Life Sciences ; Rats ; Rats, Transgenic ; 基因组 ; 大鼠 ; 实验模型 ; 小鼠模型 ; 核酸酶 ; 编辑技术 ; 药理学 ; 转录激活</subject><ispartof>Cell research, 2014-01, Vol.24 (1), p.122-125</ispartof><rights>Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><rights>Copyright © 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-b017239fbe17be9d8059a513d15e5f6106311e03457445cf7e239859e17acff33</citedby><cites>FETCH-LOGICAL-c473t-b017239fbe17be9d8059a513d15e5f6106311e03457445cf7e239859e17acff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85240X/85240X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879705/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879705/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24296780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yuanwu</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Shen, Bin</creatorcontrib><creatorcontrib>Lu, Yingdong</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Bai, Lin</creatorcontrib><creatorcontrib>Huang, Xingxu</creatorcontrib><creatorcontrib>Zhang, Lianfeng</creatorcontrib><title>Generating rats with conditional alleles using CRISPR/Cas9</title><title>Cell research</title><addtitle>Cell Res</addtitle><addtitle>Cell Research</addtitle><description>Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats （CRISPR）/CRISPR-associated 9 （Cas9） system [4-5],</description><subject>631/1647/1513</subject><subject>631/1647/334/1874/486</subject><subject>Alleles</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Clustered Regularly Interspaced Short Palindromic Repeats - genetics</subject><subject>CRISPR-Associated Proteins - genetics</subject><subject>DNA (Cytosine-5-)-Methyltransferase 1</subject><subject>DNA (Cytosine-5-)-Methyltransferases - genetics</subject><subject>DNA Methyltransferase 3A</subject><subject>DNA Methyltransferase 3B</subject><subject>Gene Knockout Techniques</subject><subject>Letter to the Editor</subject><subject>Life Sciences</subject><subject>Rats</subject><subject>Rats, Transgenic</subject><subject>基因组</subject><subject>大鼠</subject><subject>实验模型</subject><subject>小鼠模型</subject><subject>核酸酶</subject><subject>编辑技术</subject><subject>药理学</subject><subject>转录激活</subject><issn>1001-0602</issn><issn>1748-7838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkdFrFDEQh4MotlaffJdFXwTd68wm2SQ-COXQWigoVZ9DLjd7t2UvaZNdi_-9Oe88qvg0gfnyzTA_xp4jzBC4PvVp1gDyGUr1gB2jErpWmuuH5Q2ANbTQHLEnOV8DNFJIfMyOGtGYVmk4Zu_OKVByYx9WVSm5uuvHdeVjWPZjH4MbKjcMNFCuprxl5lcXX79cnc5dNk_Zo84NmZ7t6wn7_vHDt_mn-vLz-cX87LL2QvGxXgCqhptuQagWZJYapHES-RIlya5FaDkiARdSCSF9p6jQWpqCO991nJ-w9zvvzbTY0NJTGJMb7E3qNy79tNH19u9O6Nd2FX9YrpVRIIvg9V6Q4u1EebSbPnsaBhcoTtmiMKCaViAW9NU_6HWcUjnDllJctxp_U292lE8x50TdYRkEu83E-mS3mdiSSaFf3N__wP4JoQBvd0AurbCidG_of30v99PXMaxuy4-Dsm3RoNBa8l8oP58k</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Ma, Yuanwu</creator><creator>Zhang, Xu</creator><creator>Shen, Bin</creator><creator>Lu, Yingdong</creator><creator>Chen, Wei</creator><creator>Ma, Jing</creator><creator>Bai, Lin</creator><creator>Huang, Xingxu</creator><creator>Zhang, Lianfeng</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Generating rats with conditional alleles using CRISPR/Cas9</title><author>Ma, Yuanwu ; Zhang, Xu ; Shen, Bin ; Lu, Yingdong ; Chen, Wei ; Ma, Jing ; Bai, Lin ; Huang, Xingxu ; Zhang, Lianfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-b017239fbe17be9d8059a513d15e5f6106311e03457445cf7e239859e17acff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/1647/1513</topic><topic>631/1647/334/1874/486</topic><topic>Alleles</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Clustered Regularly Interspaced Short Palindromic Repeats - genetics</topic><topic>CRISPR-Associated Proteins - genetics</topic><topic>DNA (Cytosine-5-)-Methyltransferase 1</topic><topic>DNA (Cytosine-5-)-Methyltransferases - genetics</topic><topic>DNA Methyltransferase 3A</topic><topic>DNA Methyltransferase 3B</topic><topic>Gene Knockout Techniques</topic><topic>Letter to the Editor</topic><topic>Life Sciences</topic><topic>Rats</topic><topic>Rats, Transgenic</topic><topic>基因组</topic><topic>大鼠</topic><topic>实验模型</topic><topic>小鼠模型</topic><topic>核酸酶</topic><topic>编辑技术</topic><topic>药理学</topic><topic>转录激活</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yuanwu</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Shen, Bin</creatorcontrib><creatorcontrib>Lu, Yingdong</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Bai, Lin</creatorcontrib><creatorcontrib>Huang, Xingxu</creatorcontrib><creatorcontrib>Zhang, Lianfeng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats （CRISPR）/CRISPR-associated 9 （Cas9） system [4-5],</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24296780</pmid><doi>10.1038/cr.2013.157</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/1513 631/1647/334/1874/486 Alleles Animals Biomedical and Life Sciences Cell Biology Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Associated Proteins - genetics DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methyltransferase 3A DNA Methyltransferase 3B Gene Knockout Techniques Letter to the Editor Life Sciences Rats Rats, Transgenic 基因组 大鼠 实验模型 小鼠模型 核酸酶 编辑技术 药理学 转录激活 |
| title | Generating rats with conditional alleles using CRISPR/Cas9 |
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