Generating rats with conditional alleles using CRISPR/Cas9

Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the C...

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Veröffentlicht in:	Cell research 2014-01, Vol.24 (1), p.122-125
Hauptverfasser:	Ma, Yuanwu, Zhang, Xu, Shen, Bin, Lu, Yingdong, Chen, Wei, Ma, Jing, Bai, Lin, Huang, Xingxu, Zhang, Lianfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1513 631/1647/334/1874/486 Alleles Animals Biomedical and Life Sciences Cell Biology Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR-Associated Proteins - genetics DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methyltransferase 3A DNA Methyltransferase 3B Gene Knockout Techniques Letter to the Editor Life Sciences Rats Rats, Transgenic 基因组大鼠实验模型小鼠模型核酸酶编辑技术药理学转录激活
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Beschreibung
Zusammenfassung:	Dear Editor, The rat is an important laboratory model and has many advantages over mouse models especially in toxicol- ogy and pharmacology studies. Several genome-editing technologies, such as zinc-finger nucleases （ZFNs） [1-2], transcription activator-like effector nucleases （TALENs） [3] and the Clustered Regularly Interspaced Short Palin- dromic Repeats （CRISPR）/CRISPR-associated 9 （Cas9） system [4-5],
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2013.157