Polymeric Micelles for Neoadjuvant Cancer Therapy and Tumor-Primed Optical Imaging

Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles act as a 3-in-1 nanocontainer for three poorly water-soluble drugs–paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin (PTX/17-AAG/RAPA)–for cancer therapy. In a LS180 human colon xenograft model, a single intraveno...

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Veröffentlicht in:	ACS nano 2011-11, Vol.5 (11), p.8721-8729
Hauptverfasser:	Cho, Hyunah, Kwon, Glen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Cancer Cell Line, Tumor Cell Transformation, Neoplastic Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Density Drug Carriers - chemistry Female Humans Imaging Infrared Rays Iodides Lactates - chemistry Mice Micelles Molecular Imaging - methods Nanomedicine - methods Nanostructure Nanostructures - chemistry Neoadjuvant Therapy - methods Optical Phenomena Polyethylene Glycols - chemistry Strategy Therapy Tumors
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Beschreibung
Zusammenfassung:	Poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) micelles act as a 3-in-1 nanocontainer for three poorly water-soluble drugs–paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin (PTX/17-AAG/RAPA)–for cancer therapy. In a LS180 human colon xenograft model, a single intravenous (IV) injection of 3-in-1 PEG-b-PLA micelles reduced tumor volume by 1.6-fold with
ISSN:	1936-0851 1936-086X
DOI:	10.1021/nn202676u