Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye
Seeing is believing: A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is b...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2013-12, Vol.52 (52), p.14065-14069 |
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| container_issue | 52 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 52 |
| creator | Liu, Dingbin Wang, Zhantong Jin, Albert Huang, Xinglu Sun, Xiaolian Wang, Fu Yan, Qiang Ge, Shengxiang Xia, Ningshao Niu, Gang Liu, Gang Hight Walker, A. R. Chen, Xiaoyuan |
| description | Seeing is believing: A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is based on solution color change, which can be easily observed by the naked eye alone. |
| doi_str_mv | 10.1002/anie.201307952 |
| format | Article |
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KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5762-a1a1e428287ba6cb022311938f90d8ef23832f1b5505b938fb397f5f50e8003b3</citedby><cites>FETCH-LOGICAL-c5762-a1a1e428287ba6cb022311938f90d8ef23832f1b5505b938fb397f5f50e8003b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201307952$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201307952$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24155243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Dingbin</creatorcontrib><creatorcontrib>Wang, Zhantong</creatorcontrib><creatorcontrib>Jin, Albert</creatorcontrib><creatorcontrib>Huang, Xinglu</creatorcontrib><creatorcontrib>Sun, Xiaolian</creatorcontrib><creatorcontrib>Wang, Fu</creatorcontrib><creatorcontrib>Yan, Qiang</creatorcontrib><creatorcontrib>Ge, Shengxiang</creatorcontrib><creatorcontrib>Xia, Ningshao</creatorcontrib><creatorcontrib>Niu, Gang</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Hight Walker, A. R.</creatorcontrib><creatorcontrib>Chen, Xiaoyuan</creatorcontrib><title>Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye</title><title>Angewandte Chemie International Edition</title><addtitle>Angew. Chem. Int. Ed</addtitle><description>Seeing is believing: A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is based on solution color change, which can be easily observed by the naked eye alone.</description><subject>acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Amplification</subject><subject>analytical methods</subject><subject>Assaying</subject><subject>Catalysis</subject><subject>Color</subject><subject>Diagnostic systems</subject><subject>gold</subject><subject>Gold - metabolism</subject><subject>Hydrolysis</subject><subject>Metal Nanoparticles</subject><subject>nanoparticles</subject><subject>Pathogens</subject><subject>Platforms</subject><subject>Strategy</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFv0zAUxiPExMbGlSOKxIVLOtsvjp0LUlXKNlSVHTaxm-WkL4s3N95idyX89TjqqAYXTrb8ft-n997nJHlPyYQSwk51Z3DCCAUiSs5eJUeUM5qBEPA63nOATEhOD5O33t9FXkpSvEkOWU45ZzkcJWZaYxhs3TprOvQBe-0xm-mg7fALV-n5sOqdHbzx6dRat_XptQ0j03kTzBOmXzBgHYzrUteklzq07jbW0q0JbRpaTJf6PtrMBzxJDhptPb57Po-T66_zq9l5tvh-djGbLrKai4JlmmqKOZNMikoXdUUYA0pLkE1JVhIbBhJYQyvOCa_G5wpK0fCGE5SEQAXHyeed78OmWuOqxi72a9VDb9a6H5TTRv1d6Uyrbt2TAinyuJ9o8OnZoHePm7gTtTa-Rmt1h27jFRWEUsZzPqIf_0Hv3Kbv4niK5oUsc6AAkZrsqLp33vfY7JuhRI0pqjFFtU8xCj68HGGP_4ktAuUO2BqLw3_s1HR5MX9pnu20Jqb9c6_V_b0qBAiufizP1Lf4TxY39EZdwm_fmLmz</recordid><startdate>20131223</startdate><enddate>20131223</enddate><creator>Liu, Dingbin</creator><creator>Wang, Zhantong</creator><creator>Jin, Albert</creator><creator>Huang, Xinglu</creator><creator>Sun, Xiaolian</creator><creator>Wang, Fu</creator><creator>Yan, Qiang</creator><creator>Ge, Shengxiang</creator><creator>Xia, Ningshao</creator><creator>Niu, Gang</creator><creator>Liu, Gang</creator><creator>Hight Walker, A. R.</creator><creator>Chen, Xiaoyuan</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>5PM</scope></search><sort><creationdate>20131223</creationdate><title>Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye</title><author>Liu, Dingbin ; Wang, Zhantong ; Jin, Albert ; Huang, Xinglu ; Sun, Xiaolian ; Wang, Fu ; Yan, Qiang ; Ge, Shengxiang ; Xia, Ningshao ; Niu, Gang ; Liu, Gang ; Hight Walker, A. 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| subjects | acetylcholinesterase Acetylcholinesterase - metabolism Amplification analytical methods Assaying Catalysis Color Diagnostic systems gold Gold - metabolism Hydrolysis Metal Nanoparticles nanoparticles Pathogens Platforms Strategy |
| title | Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye |
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