Acetylcholinesterase-Catalyzed Hydrolysis Allows Ultrasensitive Detection of Pathogens with the Naked Eye

Seeing is believing: A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is b...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-12, Vol.52 (52), p.14065-14069
Hauptverfasser:	Liu, Dingbin, Wang, Zhantong, Jin, Albert, Huang, Xinglu, Sun, Xiaolian, Wang, Fu, Yan, Qiang, Ge, Shengxiang, Xia, Ningshao, Niu, Gang, Liu, Gang, Hight Walker, A. R., Chen, Xiaoyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Amplification analytical methods Assaying Catalysis Color Diagnostic systems gold Gold - metabolism Hydrolysis Metal Nanoparticles nanoparticles Pathogens Platforms Strategy
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Seeing is believing: A rapid diagnostic platform for pathogen detection based on the acetylcholinesterase‐catalyzed hydrolysis reaction has been developed. Owing to signal amplification strategies, the sensitivity of this assay is comparable to that of PCR. In addition, the readout of the assay is based on solution color change, which can be easily observed by the naked eye alone.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201307952