Mechanisms of transgenerational inheritance of addictive-like behaviors

Mechanisms of transgenerational inheritance of addictive-like behaviors

Highlights • Environmental exposure to drugs alters the epigenome and is transmitted to future generations. • Epigenome provides a direct mechanism for drugs to alter the genetic events involved in addiction. • Epigenetics presents a mechanism of heritability of addictive phenotypes.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2014-04, Vol.264, p.198-206
Hauptverfasser: Vassoler, F.M, Sadri-Vakili, G
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Behavior, Addictive - genetics
Epigenesis, Genetic
Female
Humans
Inheritance Patterns - genetics
Male
Neurology
Rats
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Beschreibung
Zusammenfassung:Highlights • Environmental exposure to drugs alters the epigenome and is transmitted to future generations. • Epigenome provides a direct mechanism for drugs to alter the genetic events involved in addiction. • Epigenetics presents a mechanism of heritability of addictive phenotypes.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.07.064