PKA modulates iron trafficking in the striatum via small GTPase, Rhes

Highlights • Rhes interacts with an iron importer, DMT1 via PAP7. • Rhes is not S-nitrosylated by nitric oxide. • PKA phosphorylates Rhes at the site of serine 239. • PKA-mediated phosphorylation of Rhes modulates iron trafficking.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.214-220
Hauptverfasser:	Choi, B.-R, Bang, S, Chen, Y, Cheah, J.H, Kim, S.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Biological and medical sciences Biological Transport - drug effects Biological Transport - genetics Cation Transport Proteins - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Deferoxamine - pharmacology Ferric Compounds - pharmacology Fundamental and applied biological sciences. Psychology G protein Glutathione Transferase - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism HEK293 Cells Humans Immunoprecipitation Iron - metabolism iron uptake Iron-Regulatory Proteins - genetics Iron-Regulatory Proteins - metabolism Membrane Proteins - metabolism Mutation - genetics Neurology phosphorylation Phosphorylation - drug effects Phosphorylation - genetics PKA Quaternary Ammonium Compounds - pharmacology Rhes Serine - metabolism Siderophores - pharmacology striatum Transfection Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Rhes interacts with an iron importer, DMT1 via PAP7. • Rhes is not S-nitrosylated by nitric oxide. • PKA phosphorylates Rhes at the site of serine 239. • PKA-mediated phosphorylation of Rhes modulates iron trafficking.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.08.043