The role of androgen receptor in transcriptional modulation of cannabinoid receptor type 1 gene in rat trigeminal ganglia

Highlights • IL-1β induces CB1 mRNA upregulation via androgen receptors in trigeminal ganglia. • Androgen receptor activates CB1 gene transcription in response to testosterone. • Androgen receptor binds to the promoter of CB1 gene.

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Veröffentlicht in:Neuroscience 2013-12, Vol.254, p.395-403
Hauptverfasser: Lee, K.S, Asgar, J, Zhang, Y, Chung, M.-K, Ro, J.Y
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container_title Neuroscience
container_volume 254
creator Lee, K.S
Asgar, J
Zhang, Y
Chung, M.-K
Ro, J.Y
description Highlights • IL-1β induces CB1 mRNA upregulation via androgen receptors in trigeminal ganglia. • Androgen receptor activates CB1 gene transcription in response to testosterone. • Androgen receptor binds to the promoter of CB1 gene.
doi_str_mv 10.1016/j.neuroscience.2013.09.014
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Animals
Base Sequence
Biological and medical sciences
Cell Line, Tumor
Cells, Cultured
cytokines
Female
Fundamental and applied biological sciences. Psychology
Humans
inflammation
Male
Medical sciences
Molecular Sequence Data
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Protein Binding - physiology
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
rat
Rats
Receptor, Cannabinoid, CB1 - biosynthesis
Receptor, Cannabinoid, CB1 - genetics
Receptors, Androgen - physiology
sensory neurons
testosterone
Transcription, Genetic - physiology
Trigeminal Ganglion - metabolism
Vertebrates: nervous system and sense organs
title The role of androgen receptor in transcriptional modulation of cannabinoid receptor type 1 gene in rat trigeminal ganglia
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