The role of androgen receptor in transcriptional modulation of cannabinoid receptor type 1 gene in rat trigeminal ganglia

Highlights • IL-1β induces CB1 mRNA upregulation via androgen receptors in trigeminal ganglia. • Androgen receptor activates CB1 gene transcription in response to testosterone. • Androgen receptor binds to the promoter of CB1 gene.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.395-403
Hauptverfasser:	Lee, K.S, Asgar, J, Zhang, Y, Chung, M.-K, Ro, J.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell Line, Tumor Cells, Cultured cytokines Female Fundamental and applied biological sciences. Psychology Humans inflammation Male Medical sciences Molecular Sequence Data Neurology Neuropharmacology Pharmacology. Drug treatments Protein Binding - physiology Psychodysleptics: hallucinogen Psychology. Psychoanalysis. Psychiatry Psychopharmacology rat Rats Receptor, Cannabinoid, CB1 - biosynthesis Receptor, Cannabinoid, CB1 - genetics Receptors, Androgen - physiology sensory neurons testosterone Transcription, Genetic - physiology Trigeminal Ganglion - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • IL-1β induces CB1 mRNA upregulation via androgen receptors in trigeminal ganglia. • Androgen receptor activates CB1 gene transcription in response to testosterone. • Androgen receptor binds to the promoter of CB1 gene.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.014