cAMP and mitochondria

Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still cont...

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Veröffentlicht in:	Physiology (Bethesda, Md.) Md.), 2013-05, Vol.28 (3), p.199-209
Hauptverfasser:	Valsecchi, Federica, Ramos-Espiritu, Lavoisier S, Buck, Jochen, Levin, Lonny R, Manfredi, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Animals Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Energy Metabolism Humans Mitochondria - metabolism Mitochondrial Proteins - metabolism Phosphorylation Reviews Second Messenger Systems
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Beschreibung
Zusammenfassung:	Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.
ISSN:	1548-9213 1548-9221 1548-9221
DOI:	10.1152/physiol.00004.2013