Diffused and Sustained Inhibitory Effects of Intestinal Electrical Stimulation on Intestinal Motility Mediated via Sympathetic Pathway

Objective The aims were to investigate the energy‐dose response effect of intestinal electrical stimulation (IES) on small bowel motility, to compare the effect of forward and backward IES, and to explore the possibility of using intermittent IES and mechanism of IES on intestinal motility. Materials and Methods Five dogs implanted with a duodenal cannula and one pair of intestinal serosal electrodes were studied in five sessions: 1) energy‐dose response study; 2) forward IES; 3) backward IES; 4) intermittent IES vs. continuous IES; 5) administration of guanethidine. The contractile activity and tonic pressure of the small intestine were recorded. The duration of sustained effect after turning off IES was manually calculated. Results 1) IES with long pulse energy dose dependently inhibited contractile activity and tonic pressure of the small intestine (p