The impact of exposure to addictive drugs on future generations: Physiological and behavioral effects
It is clear that both genetic and environmental factors contribute to drug addiction. Recent evidence indicating trans-generational influences of drug abuse highlight potential epigenetic factors as well. Specifically, mounting evidence suggests that parental ingestion of abused drugs influence the...
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Veröffentlicht in: | Neuropharmacology 2014-01, Vol.76 (0), p.269-275 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | It is clear that both genetic and environmental factors contribute to drug addiction. Recent evidence indicating trans-generational influences of drug abuse highlight potential epigenetic factors as well. Specifically, mounting evidence suggests that parental ingestion of abused drugs influence the physiology and behavior of future generations even in the absence of prenatal exposure. The goal of this review is to describe the trans-generational consequences of preconception exposure to drugs of abuse for five major classes of drugs: alcohol, nicotine, marijuana, opioids, and cocaine. The potential epigenetic mechanisms underlying the transmission of these phenotypes across generations also are detailed.
This article is part of a Special Issue entitled ‘NIDA 40th Anniversary Issue’.
•Transgenerational consequences of exposure to drugs of abuse.•Paternal and maternal transmission to offspring prior to conception.•Alcohol, nicotine, cannabinoids, opioids, cocaine. |
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ISSN: | 0028-3908 1873-7064 |
DOI: | 10.1016/j.neuropharm.2013.06.016 |