Effects of sex and hypertension subtype on haemodynamics and left ventricular diastolic function in older patients with stage 1 hypertension

BACKGROUND:Hypertension is associated with cardiovascular stiffening and left ventricular diastolic dysfunction, leading to comorbidities such as heart failure with preserved ejection fraction (HFpEF). It is unknown whether sex and hypertension subtype affect haemodynamics and left ventricular funct...

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Veröffentlicht in:	Journal of hypertension 2013-11, Vol.31 (11), p.2282-2289
Hauptverfasser:	Fujimoto, Naoki, Okada, Yoshiyuki, Shibata, Shigeki, Best, Stuart A., Bivens, Tiffany B., Levine, Benjamin D., Fu, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Blood Pressure Monitoring, Ambulatory Case-Control Studies Comorbidity Diastole - physiology Echocardiography, Doppler Female Humans Hypertension - physiopathology Male Middle Aged Mitral Valve - physiopathology Sex Factors Stroke Volume - physiology Supine Position - physiology Systole - physiology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - physiology
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Zusammenfassung:	BACKGROUND:Hypertension is associated with cardiovascular stiffening and left ventricular diastolic dysfunction, leading to comorbidities such as heart failure with preserved ejection fraction (HFpEF). It is unknown whether sex and hypertension subtype affect haemodynamics and left ventricular function in older individuals. METHODS:Ninety-five older patients with Stage 1 hypertension (ambulatory awake SBP135–159 mmHg) and 56 normotensive controls were enrolled. Patients were stratified prospectively into isolated systolic hypertension (ISH, DBP
ISSN:	0263-6352 1473-5598
DOI:	10.1097/HJH.0b013e3283649730