Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women
Objective Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2014-05, Vol.22 (5), p.E135-E141 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Cornelis, Marilyn C. Rimm, Eric B. Curhan, Gary C. Kraft, Peter Hunter, David J. Hu, Frank B. Dam, Rob M. |
| description | Objective
Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined.
Methods
Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome‐wide scans and a genetic‐risk score (GRS) derived from 32 obesity‐loci was calculated.
Results
The GRS was positively associated with emotional and uncontrolled eating (P |
| doi_str_mv | 10.1002/oby.20592 |
| format | Article |
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Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined.
Methods
Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome‐wide scans and a genetic‐risk score (GRS) derived from 32 obesity‐loci was calculated.
Results
The GRS was positively associated with emotional and uncontrolled eating (P<0.002). In exploratory analysis, BMI‐increasing variants of MTCH2, TNNI3K, and ZC3H4 were positively associated with emotional eating and those of TNNI3K and ZC3H4 were positively associated with uncontrolled eating. The BMI‐increasing variant of FTO was positively and those of LRP1B and TFAP2B were inversely associated with cognitive restraint. These associations for single SNPs were independent of BMI but were not significant after multiple‐testing correction.
Conclusions
An overall genetic susceptibility to obesity may also extend to eating behaviors. The link between specific loci and obesity may be mediated by eating behavior but larger studies are warranted to confirm these results.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20592</identifier><identifier>PMID: 23929626</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Behavior ; Body Mass Index ; Cardiovascular disease ; Cognition ; Cohort Studies ; Eating - genetics ; Eating - psychology ; Emotions ; Energy Intake - genetics ; Family medical history ; Feeding Behavior - psychology ; Female ; Follow-Up Studies ; Gene loci ; Genetic Loci ; Genetic Predisposition to Disease ; Genomes ; Health Behavior ; Humans ; Laboratories ; Life Style ; Lifestyles ; Linear Models ; Male ; Medical personnel ; Mens health ; Middle Aged ; Obesity ; Obesity - epidemiology ; Obesity - genetics ; Obesity - psychology ; Principal components analysis ; Public health ; Questionnaires ; Risk Factors ; Studies ; Surveys and Questionnaires ; United States - epidemiology ; Womens health</subject><ispartof>Obesity (Silver Spring, Md.), 2014-05, Vol.22 (5), p.E135-E141</ispartof><rights>2013 The Obesity Society</rights><rights>2013 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. May 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5092-c295db31902e4d88bc1573f097e2c5c6602e5787981ceef8bb8270c27ba869ed3</citedby><cites>FETCH-LOGICAL-c5092-c295db31902e4d88bc1573f097e2c5c6602e5787981ceef8bb8270c27ba869ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20592$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20592$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23929626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cornelis, Marilyn C.</creatorcontrib><creatorcontrib>Rimm, Eric B.</creatorcontrib><creatorcontrib>Curhan, Gary C.</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Hunter, David J.</creatorcontrib><creatorcontrib>Hu, Frank B.</creatorcontrib><creatorcontrib>Dam, Rob M.</creatorcontrib><title>Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined.
Methods
Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome‐wide scans and a genetic‐risk score (GRS) derived from 32 obesity‐loci was calculated.
Results
The GRS was positively associated with emotional and uncontrolled eating (P<0.002). In exploratory analysis, BMI‐increasing variants of MTCH2, TNNI3K, and ZC3H4 were positively associated with emotional eating and those of TNNI3K and ZC3H4 were positively associated with uncontrolled eating. The BMI‐increasing variant of FTO was positively and those of LRP1B and TFAP2B were inversely associated with cognitive restraint. These associations for single SNPs were independent of BMI but were not significant after multiple‐testing correction.
Conclusions
An overall genetic susceptibility to obesity may also extend to eating behaviors. The link between specific loci and obesity may be mediated by eating behavior but larger studies are warranted to confirm these results.</description><subject>Adult</subject><subject>Behavior</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Cognition</subject><subject>Cohort Studies</subject><subject>Eating - genetics</subject><subject>Eating - psychology</subject><subject>Emotions</subject><subject>Energy Intake - genetics</subject><subject>Family medical history</subject><subject>Feeding Behavior - psychology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene loci</subject><subject>Genetic Loci</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Health Behavior</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - genetics</subject><subject>Obesity - psychology</subject><subject>Principal components analysis</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Surveys and Questionnaires</subject><subject>United States - epidemiology</subject><subject>Womens health</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctqGzEUhkVoSdI0i7xAEXSTQp3oYs1Im0AaeoOANy20KyFpjh0FjeRKM0799lVs1ySFrs7t4-ec8yN0RskFJYRdJru-YEQodoCOqeJk0nL148U-l_QIvSrlnpBpQwQ9REeMK6Ya1hyj3zMLxQ9rXMbiYDl468NjGZLz2MQOj9GlOOQUAnQYzODj4j2GPg0-RRN2nQ3p0iL6wa8AZyhDNj4O2MKdWfmUC_YR9xA34EOq2Wv0cm5CgdNdPEHfP338dvNlcjv7_PXm-nbiBFFs4pgSneVUEQbTTkrrqGj5nKgWmBOuaWpftLJVkjqAubRWspY41lojGwUdP0FXW93laHvoHNRjTNDL7HuT1zoZr59Por_Ti7TSXAo5ZawKnO8Ecvo11st07-urQjAR0lg0FYzyKeGUVPTtP-h9GnN9U6WaVlDFCFOVerelXE6lZJjvl6FEP_qpq59642dl3zzdfk_-NbACl1vgwQdY_19Jzz783Er-AeGtrNY</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Cornelis, Marilyn C.</creator><creator>Rimm, Eric B.</creator><creator>Curhan, Gary C.</creator><creator>Kraft, Peter</creator><creator>Hunter, David J.</creator><creator>Hu, Frank B.</creator><creator>Dam, Rob M.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201405</creationdate><title>Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women</title><author>Cornelis, Marilyn C. ; Rimm, Eric B. ; Curhan, Gary C. ; Kraft, Peter ; Hunter, David J. ; Hu, Frank B. ; Dam, Rob M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5092-c295db31902e4d88bc1573f097e2c5c6602e5787981ceef8bb8270c27ba869ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Behavior</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Cognition</topic><topic>Cohort Studies</topic><topic>Eating - genetics</topic><topic>Eating - psychology</topic><topic>Emotions</topic><topic>Energy Intake - genetics</topic><topic>Family medical history</topic><topic>Feeding Behavior - psychology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene loci</topic><topic>Genetic Loci</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Health Behavior</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Life Style</topic><topic>Lifestyles</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - genetics</topic><topic>Obesity - psychology</topic><topic>Principal components analysis</topic><topic>Public health</topic><topic>Questionnaires</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Surveys and Questionnaires</topic><topic>United States - epidemiology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cornelis, Marilyn C.</creatorcontrib><creatorcontrib>Rimm, Eric B.</creatorcontrib><creatorcontrib>Curhan, Gary C.</creatorcontrib><creatorcontrib>Kraft, Peter</creatorcontrib><creatorcontrib>Hunter, David J.</creatorcontrib><creatorcontrib>Hu, Frank B.</creatorcontrib><creatorcontrib>Dam, Rob M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cornelis, Marilyn C.</au><au>Rimm, Eric B.</au><au>Curhan, Gary C.</au><au>Kraft, Peter</au><au>Hunter, David J.</au><au>Hu, Frank B.</au><au>Dam, Rob M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2014-05</date><risdate>2014</risdate><volume>22</volume><issue>5</issue><spage>E135</spage><epage>E141</epage><pages>E135-E141</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined.
Methods
Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome‐wide scans and a genetic‐risk score (GRS) derived from 32 obesity‐loci was calculated.
Results
The GRS was positively associated with emotional and uncontrolled eating (P<0.002). In exploratory analysis, BMI‐increasing variants of MTCH2, TNNI3K, and ZC3H4 were positively associated with emotional eating and those of TNNI3K and ZC3H4 were positively associated with uncontrolled eating. The BMI‐increasing variant of FTO was positively and those of LRP1B and TFAP2B were inversely associated with cognitive restraint. These associations for single SNPs were independent of BMI but were not significant after multiple‐testing correction.
Conclusions
An overall genetic susceptibility to obesity may also extend to eating behaviors. The link between specific loci and obesity may be mediated by eating behavior but larger studies are warranted to confirm these results.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23929626</pmid><doi>10.1002/oby.20592</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2014-05, Vol.22 (5), p.E135-E141 |
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| subjects | Adult Behavior Body Mass Index Cardiovascular disease Cognition Cohort Studies Eating - genetics Eating - psychology Emotions Energy Intake - genetics Family medical history Feeding Behavior - psychology Female Follow-Up Studies Gene loci Genetic Loci Genetic Predisposition to Disease Genomes Health Behavior Humans Laboratories Life Style Lifestyles Linear Models Male Medical personnel Mens health Middle Aged Obesity Obesity - epidemiology Obesity - genetics Obesity - psychology Principal components analysis Public health Questionnaires Risk Factors Studies Surveys and Questionnaires United States - epidemiology Womens health |
| title | Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women |
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