Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women

Obesity susceptibility loci and uncontrolled eating, emotional eating and cognitive restraint behaviors in men and women

Objective Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2014-05, Vol.22 (5), p.E135-E141
Hauptverfasser: Cornelis, Marilyn C., Rimm, Eric B., Curhan, Gary C., Kraft, Peter, Hunter, David J., Hu, Frank B., Dam, Rob M.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Behavior
Body Mass Index
Cardiovascular disease
Cognition
Cohort Studies
Eating - genetics
Eating - psychology
Emotions
Energy Intake - genetics
Family medical history
Feeding Behavior - psychology
Female
Follow-Up Studies
Gene loci
Genetic Loci
Genetic Predisposition to Disease
Genomes
Health Behavior
Humans
Laboratories
Life Style
Lifestyles
Linear Models
Male
Medical personnel
Mens health
Middle Aged
Obesity
Obesity - epidemiology
Obesity - genetics
Obesity - psychology
Principal components analysis
Public health
Questionnaires
Risk Factors
Studies
Surveys and Questionnaires
United States - epidemiology
Womens health
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Zusammenfassung:Objective Many confirmed genetic loci for obesity are expressed in regions of the brain that regulate energy intake and reward‐seeking behavior. Whether these loci contribute to the development of specific eating behaviors has not been investigated. The relationship between a genetic susceptibility to obesity and cognitive restraint, uncontrolled and emotional eating was examined. Methods Eating behavior and body mass index (BMI) were determined by questionnaires for 1471 men and 2381 women from two US cohorts. Genotypes were extracted from genome‐wide scans and a genetic‐risk score (GRS) derived from 32 obesity‐loci was calculated. Results The GRS was positively associated with emotional and uncontrolled eating (P
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.20592