Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis

Melanoma brain metastasis (MBM) represents a frequent complication of cutaneous melanoma. Despite aggressive multi-modality therapy, patients with MBM often have a survival rate of

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Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2014-01, Vol.23 (1), p.226-238
Hauptverfasser:	Marzese, Diego M, Scolyer, Richard A, Huynh, Jamie L, Huang, Sharon K, Hirose, Hajime, Chong, Kelly K, Kiyohara, Eiji, Wang, Jinhua, Kawas, Neal P, Donovan, Nicholas C, Hata, Keisuke, Wilmott, James S, Murali, Rajmohan, Buckland, Michael E, Shivalingam, Brindha, Thompson, John F, Morton, Donald L, Kelly, Daniel F, Hoon, Dave S B
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Brain Neoplasms - genetics Brain Neoplasms - secondary Cell Line, Tumor Cohort Studies CpG Islands Disease Progression DNA Methylation Epigenesis, Genetic Gene Expression Profiling Genes, Homeobox Genome, Human Homeodomain Proteins - genetics Humans Lymphatic Metastasis Melanoma - genetics Melanoma - pathology Melanoma, Cutaneous Malignant Molecular Sequence Data Neoplasm Proteins - genetics Oligonucleotide Array Sequence Analysis Prognosis Promoter Regions, Genetic Skin Neoplasms Survival Rate Treatment Outcome
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Beschreibung
Zusammenfassung:	Melanoma brain metastasis (MBM) represents a frequent complication of cutaneous melanoma. Despite aggressive multi-modality therapy, patients with MBM often have a survival rate of
ISSN:	0964-6906 1460-2083
DOI:	10.1093/hmg/ddt420