Candida skin test reagent as a novel adjuvant for a human papillomavirus peptide-based therapeutic vaccine

Highlights • The vaccine antigens are 4 human papillomavirus type 16 E6 peptides. • Candida skin test reagent is the vaccine adjuvant. • The partial Langerhans cell maturation effects are due to the peptides. • Candida has the T-cell proliferative effect. • IL-12 is the most commonly expressed cytok...

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Veröffentlicht in:	Vaccine 2013-12, Vol.31 (49), p.5806-5813
Hauptverfasser:	Wang, Xuelian, Coleman, Hannah N, Nagarajan, Uma, Spencer, Horace J, Nakagawa, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Adjuvants, Immunologic - pharmacology Allergy and Immunology Applied microbiology Biological and medical sciences Candida Candida - immunology Candida albicans CD4-Positive T-Lymphocytes - immunology Cell Proliferation cell-mediated immunity Cells, Cultured clinical trials Cytokines - immunology Fundamental and applied biological sciences. Psychology Human papillomavirus Humans immune response Immunity, Cellular interferon-gamma interleukin-10 interleukin-12 interleukin-1beta interleukin-6 interleukin-8 Langerhans cells Langerhans Cells - immunology mannose messenger RNA Microbiology Miscellaneous Mycology Papillomavirus Vaccines - immunology peptides receptors secretion T-lymphocytes tumor necrosis factor-alpha vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
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Beschreibung
Zusammenfassung:	Highlights • The vaccine antigens are 4 human papillomavirus type 16 E6 peptides. • Candida skin test reagent is the vaccine adjuvant. • The partial Langerhans cell maturation effects are due to the peptides. • Candida has the T-cell proliferative effect. • IL-12 is the most commonly expressed cytokine by the Langerhans cells.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.10.014