Th17-mediated inflammation in asthma

Th17-mediated inflammation in asthma

Highlights • Th17 cells and cytokines are associated with the more severe phenotypes of asthma. • IL-17A and IL-17F are associated with increased neutrophils in the airway. • IL-17A, IL-17F, and IL-22 increase airway mucus production and smooth muscle mass.

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Bibliographische Detailangaben
Veröffentlicht in:Current opinion in immunology 2013-12, Vol.25 (6), p.755-760
Hauptverfasser: Newcomb, Dawn C, Peebles, R Stokes
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Asthma - immunology
Asthma - therapy
Humans
Inflammation - immunology
Inflammation Mediators - immunology
Interleukin-17 - immunology
Interleukin-22
Interleukins - immunology
Th17 Cells - immunology
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Beschreibung
Zusammenfassung:Highlights • Th17 cells and cytokines are associated with the more severe phenotypes of asthma. • IL-17A and IL-17F are associated with increased neutrophils in the airway. • IL-17A, IL-17F, and IL-22 increase airway mucus production and smooth muscle mass.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2013.08.002