Analysis of brain nuclei accessible to ghrelin present in the cerebrospinal fluid

Highlights • Cerebrospinal fluid ghrelin reaches most brain areas expressing ghrelin receptors. • Ependymal cells are able to uptake ghrelin present in the cerebrospinal fluid. • Ghrelin uptake in ependymal cells occurs in a ghrelin receptor-independent manner.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.253, p.406-415
Hauptverfasser:	Cabral, A, Fernandez, G, Perello, M
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl-ghrelin Animals Biological and medical sciences Brain - drug effects Brain - physiology Eating - drug effects ependymal cells Fluorescein - pharmacokinetics Fundamental and applied biological sciences. Psychology Ghrelin - cerebrospinal fluid Ghrelin - pharmacology GHSR hypothalamus Mice Mice, Inbred C57BL Mice, Knockout Neurology Receptors, Ghrelin - deficiency Receptors, Ghrelin - genetics Receptors, Ghrelin - metabolism RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Cerebrospinal fluid ghrelin reaches most brain areas expressing ghrelin receptors. • Ependymal cells are able to uptake ghrelin present in the cerebrospinal fluid. • Ghrelin uptake in ependymal cells occurs in a ghrelin receptor-independent manner.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.008