The role of ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review

Non-alcoholic steatohepatitis (NASH) is a condition that occurs during the progression of non-alcoholic fatty liver disease. Effective therapy for NASH is still lacking. In this study, we investigated the effects of Ursodeoxycholic acid (UDCA) in the treatment of NASH. Western and Chinese databases...

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Veröffentlicht in:	BMC gastroenterology 2013-09, Vol.13 (1), p.140-140, Article 140
Hauptverfasser:	Xiang, Zun, Chen, Yi-peng, Ma, Kui-fen, Ye, Yue-fang, Zheng, Lin, Yang, Yi-da, Li, You-ming, Jin, Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Care and treatment Chinese medicine Cholagogues and Choleretics - therapeutic use Clinical trials Diabetes Disease Drug dosages Endoplasmic reticulum Fatty liver Fatty Liver - drug therapy Gastroenterology Gastrointestinal surgery Gene expression Histology Hospitals Humans Liver Liver cirrhosis Methods Non-alcoholic Fatty Liver Disease Patient outcomes Studies Treatment Outcome Type 2 diabetes Ultrasonic imaging Ursodeoxycholic Acid - therapeutic use Ursodiol Weight control
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Zusammenfassung:	Non-alcoholic steatohepatitis (NASH) is a condition that occurs during the progression of non-alcoholic fatty liver disease. Effective therapy for NASH is still lacking. In this study, we investigated the effects of Ursodeoxycholic acid (UDCA) in the treatment of NASH. Western and Chinese databases were searched by independent investigators using appropriate MESH headings to identify randomized, controlled Western and Chinese clinical trials, published between January 1990 and October 2012, testing the effects of UDCA in patients with NASH. Patient characteristics and trial endpoints were analyzed, with quality assessment according to widely acknowledged criteria. P
ISSN:	1471-230X 1471-230X
DOI:	10.1186/1471-230X-13-140