Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation

Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years : High Frequency of Deletions and G-to-A Hypermutation

To investigate if Korean red ginseng (KRG) affects vif gene, we determined vif gene over 20 years in 10 long-term slowly progressing patients (LTSP) who were treated with KRG alone and then KRG plus HAART. We also compared these data with those of 21 control patients who did not receive KRG. Control...

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Veröffentlicht in:Evidence-based complementary and alternative medicine 2013-01, Vol.2013 (2013), p.1-12
Hauptverfasser: Cho, Young Keol, Kim, Ba Reum, Chang, Mee Soo, Kim, Jung Eun
Format: Artikel
Sprache:eng
Schlagworte:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Defects
Drug therapy
Gene amplification
Ginseng
Highly active antiretroviral therapy
HIV
Human immunodeficiency virus
Lymphocytes
Nonsense mutation
Patients
Stop codon
Vif gene
Virology
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Zusammenfassung:To investigate if Korean red ginseng (KRG) affects vif gene, we determined vif gene over 20 years in 10 long-term slowly progressing patients (LTSP) who were treated with KRG alone and then KRG plus HAART. We also compared these data with those of 21 control patients who did not receive KRG. Control patient group harbored only one premature stop codon (PSC) (0.9%), whereas the 10 LTSP revealed 78 defective genes (18.1%) (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2013/871648