Building synthetic cellular organization

Building synthetic cellular organization

The elaborate spatial organization of cells enhances, restricts, and regulates protein-protein interactions. However, the biological significance of this organization has been difficult to study without ways of directly perturbing it. We highlight synthetic biology tools for engineering novel cellul...

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Veröffentlicht in:Molecular biology of the cell 2013-12, Vol.24 (23), p.3585-3587
Hauptverfasser: Polka, Jessica K, Silver, Pamela A
Format: Artikel
Sprache:eng
Schlagworte:
Artificial Cells - metabolism
Models, Biological
Subcellular Fractions - metabolism
Synthetic Biology - methods
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Beschreibung
Zusammenfassung:The elaborate spatial organization of cells enhances, restricts, and regulates protein-protein interactions. However, the biological significance of this organization has been difficult to study without ways of directly perturbing it. We highlight synthetic biology tools for engineering novel cellular organization, describing how they have been, and can be, used to advance cell biology.
ISSN:1059-1524
1939-4586
DOI:10.1091/mbc.E13-03-0155