Progranulin: at the interface of neurodegenerative and metabolic diseases
Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum p...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2013-12, Vol.24 (12), p.597-606 |
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| container_issue | 12 |
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| container_title | Trends in endocrinology and metabolism |
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| creator | Nguyen, Andrew D Nguyen, Thi A Martens, Lauren Herl Mitic, Laura L Farese, Robert V |
| description | Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum progranulin levels. • Grn −/− mice are protected from diet-induced obesity and insulin resistance. |
| doi_str_mv | 10.1016/j.tem.2013.08.003 |
| format | Article |
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All rights reserved.</rights><rights>2013 Elsevier Ltd. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-e79ae43a587b55c7a697c75a88fdc63e5330dd45ce519ba6f086a1bb2b72a62e3</citedby><cites>FETCH-LOGICAL-c605t-e79ae43a587b55c7a697c75a88fdc63e5330dd45ce519ba6f086a1bb2b72a62e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tem.2013.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24035620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Andrew D</creatorcontrib><creatorcontrib>Nguyen, Thi A</creatorcontrib><creatorcontrib>Martens, Lauren Herl</creatorcontrib><creatorcontrib>Mitic, Laura L</creatorcontrib><creatorcontrib>Farese, Robert V</creatorcontrib><title>Progranulin: at the interface of neurodegenerative and metabolic diseases</title><title>Trends in endocrinology and metabolism</title><addtitle>Trends Endocrinol Metab</addtitle><description>Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum progranulin levels. • Grn −/− mice are protected from diet-induced obesity and insulin resistance.</description><subject>Animals</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Endocrinology & Metabolism</subject><subject>Frontotemporal Dementia - genetics</subject><subject>Frontotemporal Dementia - metabolism</subject><subject>Humans</subject><subject>Insulin Resistance - genetics</subject><subject>Insulin Resistance - physiology</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Metabolic Diseases - genetics</subject><subject>Metabolic Diseases - metabolism</subject><subject>Neurodegenerative Diseases - genetics</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk-L1TAUxYsozjj6AdxIl25ab5ImzVMYkME_AwMK6jrcprdv8myTMUkfzLc3jzcO6kJXuZBzDjf5nap6zqBlwNSrXZtpaTkw0YJuAcSD6pTpftMIUOxhmaETDe8VnFRPUtoBsE4z-bg64R0IqTicVpefY9hG9Ovs_Osac52vqXY-U5zQUh2m2tMaw0hb8hQxuz3V6Md6oYxDmJ2tR5cIE6Wn1aMJ50TP7s6z6tv7d18vPjZXnz5cXry9aqwCmRvqN0idQKn7QUrbo9r0tpeo9TRaJUgKAePYSUuSbQZUE2iFbBj40HNUnMRZdX7MvVmHhUZLPkeczU10C8ZbE9CZP2-8uzbbsDdCd1xoKAEv7wJi-LFSymZxydI8o6ewJsNk1wEDrvr_SzvFmVZM8SJlR6mNIaVI0_1GDMyBltmZQsscaBnQptAqnhe_P-Xe8QtPEbw5Cqh86N5RNMk68pZGF8lmMwb3z_jzv9y2UHYW5-90S2kX1ugLKcNM4gbMl0NdDm1hojRFSCl-AmJguw8</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Nguyen, Andrew D</creator><creator>Nguyen, Thi A</creator><creator>Martens, Lauren Herl</creator><creator>Mitic, Laura L</creator><creator>Farese, Robert V</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Progranulin: at the interface of neurodegenerative and metabolic diseases</title><author>Nguyen, Andrew D ; Nguyen, Thi A ; Martens, Lauren Herl ; Mitic, Laura L ; Farese, Robert V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-e79ae43a587b55c7a697c75a88fdc63e5330dd45ce519ba6f086a1bb2b72a62e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Endocrinology & Metabolism</topic><topic>Frontotemporal Dementia - genetics</topic><topic>Frontotemporal Dementia - metabolism</topic><topic>Humans</topic><topic>Insulin Resistance - genetics</topic><topic>Insulin Resistance - physiology</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Metabolic Diseases - genetics</topic><topic>Metabolic Diseases - metabolism</topic><topic>Neurodegenerative Diseases - genetics</topic><topic>Neurodegenerative Diseases - metabolism</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Andrew D</creatorcontrib><creatorcontrib>Nguyen, Thi A</creatorcontrib><creatorcontrib>Martens, Lauren Herl</creatorcontrib><creatorcontrib>Mitic, Laura L</creatorcontrib><creatorcontrib>Farese, Robert V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Andrew D</au><au>Nguyen, Thi A</au><au>Martens, Lauren Herl</au><au>Mitic, Laura L</au><au>Farese, Robert V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progranulin: at the interface of neurodegenerative and metabolic diseases</atitle><jtitle>Trends in endocrinology and metabolism</jtitle><addtitle>Trends Endocrinol Metab</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>24</volume><issue>12</issue><spage>597</spage><epage>606</epage><pages>597-606</pages><issn>1043-2760</issn><eissn>1879-3061</eissn><abstract>Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum progranulin levels. • Grn −/− mice are protected from diet-induced obesity and insulin resistance.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>24035620</pmid><doi>10.1016/j.tem.2013.08.003</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1043-2760 |
| ispartof | Trends in endocrinology and metabolism, 2013-12, Vol.24 (12), p.597-606 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Endocrinology & Metabolism Frontotemporal Dementia - genetics Frontotemporal Dementia - metabolism Humans Insulin Resistance - genetics Insulin Resistance - physiology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Metabolic Diseases - genetics Metabolic Diseases - metabolism Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Obesity - genetics Obesity - metabolism |
| title | Progranulin: at the interface of neurodegenerative and metabolic diseases |
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