Progranulin: at the interface of neurodegenerative and metabolic diseases

Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum p...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2013-12, Vol.24 (12), p.597-606
Hauptverfasser:	Nguyen, Andrew D, Nguyen, Thi A, Martens, Lauren Herl, Mitic, Laura L, Farese, Robert V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Endocrinology & Metabolism Frontotemporal Dementia - genetics Frontotemporal Dementia - metabolism Humans Insulin Resistance - genetics Insulin Resistance - physiology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Metabolic Diseases - genetics Metabolic Diseases - metabolism Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Obesity - genetics Obesity - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Progranulin is a secreted glycoprotein found in plasma and CSF. • Progranulin has growth factor-like and inflammation-related properties. • Progranulin deficiency causes a neurodegenerative disease – frontotemporal dementia. • Obese and type 2 diabetic individuals have increased serum progranulin levels. • Grn −/− mice are protected from diet-induced obesity and insulin resistance.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2013.08.003