Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures

Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures

Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue archi...

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Veröffentlicht in:Advanced materials (Weinheim) 2013-02, Vol.25 (8), p.1192-1198
Hauptverfasser: Gurkan, Umut Atakan, Fan, Yantao, Xu, Feng, Erkmen, Burcu, Urkac, Emel Sokullu, Parlakgul, Gunes, Bernstein, Jacob, Xing, Wangli, Boyden, Edward S., Demirci, Utkan
Format: Artikel
Sprache:eng
Schlagworte:
advanced manufacturing
Animals
Architecture
biofabrication
biomanufacturing
brain engineering
Cells, Cultured
Cellular
Cellular structure
Embryonic Stem Cells - cytology
Fluorescent Dyes - chemistry
Human Umbilical Vein Endothelial Cells
Humans
Hydrogels - chemistry
Integrated circuits
Mice
neural engineering
Neurons - cytology
NIH 3T3 Cells
Philosophy
Photolithography
Polymers - chemistry
Semiconductors
three-dimensional microfabrication
Tissue Engineering
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Beschreibung
Zusammenfassung:Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt this philosophy for tissue engineering with a versatile, scalable, and generalizable microfabrication approach to create engineered tissue architectures composed of digitally specifiable building blocks, each with tuned structural, cellular, and compositional features.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201203261