Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

EGF‐modified Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide‐targeted Au NPs. Compared to the untargeted conjugates, EGF...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-08, Vol.7 (16), p.2301-2306
Hauptverfasser:	Cheng, Yu, Meyers, Joseph D., Agnes, Richard S., Doane, Tennyson L., Kenney, Malcolm E., Broome, Ann-Marie, Burda, Clemens, Basilion, James P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - drug therapy Brain Neoplasms - metabolism brain tumors Cell Line, Tumor Delayed-Action Preparations Epidermal Growth Factor - chemistry Epidermal Growth Factor - pharmacokinetics ErbB Receptors - metabolism Glioma - drug therapy Glioma - metabolism Gold - therapeutic use gold nanoparticles Humans Hydrophobic and Hydrophilic Interactions Indoles - administration & dosage Indoles - chemistry Isoindoles Metal Nanoparticles - therapeutic use Metal Nanoparticles - ultrastructure Mice Nanocapsules - chemistry Nanocapsules - ultrastructure Nanoconjugates - therapeutic use Nanoconjugates - ultrastructure nanomedicine Photochemotherapy - methods photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry targeted delivery Treatment Outcome
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Zusammenfassung:	EGF‐modified Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide‐targeted Au NPs. Compared to the untargeted conjugates, EGF–Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard‐to‐reach cancers.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201100628