Synthesis of a High-Purity Chemical Library Reveals a Potent Inducer of Oxidative Stress

Needle in a haystack: Synthesis of a high‐purity, biogenic, heterocyclic, 936‐member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2010-06, Vol.11 (9), p.1224-1227
Hauptverfasser:	Cui, Jiayue, Matsumoto, Kenji, Wang, Cindy Y, Peter, Marcus E, Kozmin, Sergey A
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Caspase 3 - metabolism Caspase 7 - metabolism caspases Cell Line, Tumor chemical libraries cytotoxicity High-Throughput Screening Assays Humans Oxidative Stress reactive oxygen species Reactive Oxygen Species - metabolism Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Sulfonylurea Compounds - chemical synthesis Sulfonylurea Compounds - chemistry Sulfonylurea Compounds - pharmacology
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Beschreibung
Zusammenfassung:	Needle in a haystack: Synthesis of a high‐purity, biogenic, heterocyclic, 936‐member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused cell death by activating both caspase‐dependent and ‐independent pathways.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201000193