Outcome of adolescents and young adults with acute myeloid leukemia treated on COG trials compared to CALGB and SWOG trials

BACKGROUND A retrospective meta‐analysis of adolescents and young adults (AYAs) with acute myeloid leukemia (AML) was performed to determine if differences in outcome exist following treatment on pediatric versus adult oncology treatment regimens. METHODS Outcomes were compared of 517 AYAs with AML...

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Veröffentlicht in:	Cancer 2013-12, Vol.119 (23), p.4170-4179
Hauptverfasser:	Woods, William G., Franklin, Anna R. K., Alonzo, Todd A., Gerbing, Robert B., Donohue, Kathleen A., Othus, Megan, Horan, John, Appelbaum, Frederick R., Estey, Elihu H., Bloomfield, Clara D., Larson, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute myeloid leukemia Adolescent adolescents Adult Age Factors antineoplastic combined chemotherapy protocols Biological and medical sciences Disease-Free Survival Female Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Proportional Hazards Models Retrospective Studies Tumors Young Adult young adults
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Zusammenfassung:	BACKGROUND A retrospective meta‐analysis of adolescents and young adults (AYAs) with acute myeloid leukemia (AML) was performed to determine if differences in outcome exist following treatment on pediatric versus adult oncology treatment regimens. METHODS Outcomes were compared of 517 AYAs with AML aged 16 to 21 years who were treated on Children's Oncology Group (COG), Cancer and Leukemia Group B (CALGB), and Southwest Oncology Group (SWOG) frontline AML trials from 1986 to 2008. RESULTS There was a significant age difference between AYA cohorts in the COG, CALGB, and SWOG trials (median, 17.2 versus 20.1 versus 19.8 years, P
ISSN:	0008-543X 1097-0142
DOI:	10.1002/cncr.28344