Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes

Highlights • We review the physiology of flushes and CNS heat-defense pathways. • Hypothalamic KNDy neurons are markedly altered in postmenopausal women. • KNDy neurons may influence thermoregulation via projections to preoptic thermoregulatory areas. • Activation of neurokinin 3 receptors in the Mn...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in neuroendocrinology 2013-08, Vol.34 (3), p.211-227
Hauptverfasser:	Rance, Naomi E, Dacks, Penny A, Mittelman-Smith, Melinda A, Romanovsky, Andrej A, Krajewski-Hall, Sally J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Body Temperature Regulation - drug effects Body Temperature Regulation - physiology Dynorphins - physiology Endocrinology & Metabolism Estradiol - pharmacology Estrogen Estrous Cycle - drug effects Female GnRH Hot Flashes - physiopathology Humans Hypothalamus - metabolism Kisspeptins - physiology Luteinizing Hormone - secretion Menopause Models, Biological Neurokinin B - physiology Neurons - physiology Ovariectomy Postmenopause - physiology Preoptic Area - metabolism Rats Receptors, Neurokinin-3 - metabolism Reproduction Signal Transduction Skin - blood supply Tail - blood supply Thermoregulation Vasodilation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We review the physiology of flushes and CNS heat-defense pathways. • Hypothalamic KNDy neurons are markedly altered in postmenopausal women. • KNDy neurons may influence thermoregulation via projections to preoptic thermoregulatory areas. • Activation of neurokinin 3 receptors in the MnPO reduces body temperature. • KNDy neurons facilitate cutaneous vasodilatation, a cardinal feature of a hot flush.
ISSN:	0091-3022 1095-6808
DOI:	10.1016/j.yfrne.2013.07.003