The Atlas genome assembly system

The Atlas genome assembly system

Atlas is a suite of programs developed for assembly of genomes by a "combined approach" that uses DNA sequence reads from both BACs and whole-genome shotgun (WGS) libraries. The BAC clones afford advantages of localized assembly with reduced computational load, and provide a robust method...

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Veröffentlicht in:Genome research 2004-04, Vol.14 (4), p.721-732
Hauptverfasser: Havlak, Paul, Chen, Rui, Durbin, K James, Egan, Amy, Ren, Yanru, Song, Xing-Zhi, Weinstock, George M, Gibbs, Richard A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chromosomes, Artificial, Bacterial - genetics
Contig Mapping - methods
Genome
Rats
Resources
Software - trends
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Beschreibung
Zusammenfassung:Atlas is a suite of programs developed for assembly of genomes by a "combined approach" that uses DNA sequence reads from both BACs and whole-genome shotgun (WGS) libraries. The BAC clones afford advantages of localized assembly with reduced computational load, and provide a robust method for dealing with repeated sequences. Inclusion of WGS sequences facilitates use of different clone insert sizes and reduces data production costs. A core function of Atlas software is recruitment of WGS sequences into appropriate BACs based on sequence overlaps. Because construction of consensus sequences is from local assembly of these reads, only small (
ISSN:1088-9051
DOI:10.1101/gr.2264004