The role of targeted viral load testing in diagnosing virological failure in children on antiretroviral therapy with immunological failure

Objectives To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV‐infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is performed in children identified as having immunologic...

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Veröffentlicht in:	Tropical medicine & international health 2012-11, Vol.17 (11), p.1386-1390
Hauptverfasser:	Davies, Mary‐Ann, Boulle, Andrew, Technau, Karl, Eley, Brian, Moultrie, Harry, Rabie, Helena, Garone, Daniela, Giddy, Janet, Wood, Robin, Egger, Matthias, Keiser, Olivia
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral therapy antirétroviral Antiviral agents Biological and medical sciences CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology Child Child, Preschool children Drug Monitoring - methods enfants fallo inmunológico fallo virológico General aspects HIV HIV Infections - drug therapy HIV Infections - virology Human viral diseases Humans immunological failure Infant Infectious diseases Medical sciences monitoring monitorización niños Pharmacology. Drug treatments Predictive Value of Tests RNA, Viral - blood South Africa suivi terapia antirretroviral thérapie Treatment Outcome VIH Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load virological failure échec immunologique échec virologique VIH
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Zusammenfassung:	Objectives To determine the improvement in positive predictive value of immunological failure criteria for identifying virological failure in HIV‐infected children on antiretroviral therapy (ART) when a single targeted viral load measurement is performed in children identified as having immunological failure. Methods Analysis of data from children (5000 copies/ml on two consecutive occasions
ISSN:	1360-2276 1365-3156
DOI:	10.1111/j.1365-3156.2012.03073.x