Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer’s disease

Highlights • Rabbits fed cholesterol develop increased ventricle volume and decreased vascular diameter. • These indices of pathology are similar to those seen in Alzheimer’s disease. • Cholesterol may induce hepatotoxicity requiring careful titration or even cessation of the diet.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.61-69
Hauptverfasser:	Schreurs, B.G, Smith-Bell, C.A, Lemieux, S.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer’s disease animal model Animals Biological and medical sciences Cerebral Arteries - pathology Cerebral Ventricles - pathology Cerebrovascular Circulation - physiology cerebrovasculature Cholesterol, Dietary - administration & dosage Cholesterol, Dietary - adverse effects copper Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Male Medical sciences MRI Neurology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rabbits ventricle
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Beschreibung
Zusammenfassung:	Highlights • Rabbits fed cholesterol develop increased ventricle volume and decreased vascular diameter. • These indices of pathology are similar to those seen in Alzheimer’s disease. • Cholesterol may induce hepatotoxicity requiring careful titration or even cessation of the diet.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.015