Tuning the cell fate of neurons and glia by microRNAs

Tuning the cell fate of neurons and glia by microRNAs

Highlights • miRNAs are small noncoding RNAs that normally silence target gene expression. • Many miRNAs have enriched expression in the central nervous system. • miRNAs are required for proliferation and differentiation of neural stem cells. • Neuronal subtypes are specified by miRNAs by suppressin...

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Veröffentlicht in:Current opinion in neurobiology 2013-12, Vol.23 (6), p.928-934
Hauptverfasser: Bian, Shan, Xu, Tian-le, Sun, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation - genetics
Gene Expression Regulation, Developmental - genetics
Humans
MicroRNAs - genetics
Neural Stem Cells - cytology
Neuroglia - cytology
Neurology
Neurons - cytology
Psychiatry
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Beschreibung
Zusammenfassung:Highlights • miRNAs are small noncoding RNAs that normally silence target gene expression. • Many miRNAs have enriched expression in the central nervous system. • miRNAs are required for proliferation and differentiation of neural stem cells. • Neuronal subtypes are specified by miRNAs by suppressing specific target genes. • Networks of miRNA-target are critical in cell fate determination of neurons and glia.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2013.08.002