Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients' prognosis

SOX9 plays an important role in bone formation and tumorigenesis. However, its involvement in osteosarcoma is still unclear. The aim of this study was to investigate the expression pattern and the clinical significance of SOX9 in human osteosarcoma. SOX9 mRNA and protein expression levels were detec...

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Veröffentlicht in:Diagnostic pathology 2013-11, Vol.8 (1), p.183-183, Article 183
Hauptverfasser: Zhu, Haibo, Tang, Jie, Tang, Mingjie, Cai, Haikang
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Sprache:eng
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Zusammenfassung:SOX9 plays an important role in bone formation and tumorigenesis. However, its involvement in osteosarcoma is still unclear. The aim of this study was to investigate the expression pattern and the clinical significance of SOX9 in human osteosarcoma. SOX9 mRNA and protein expression levels were detected by RT-PCR and Western blot assays, respectively, using 30 pairs of osteosarcoma and noncancerous bone tissues. Then, immunohistochemistry was performed to analyze the association of SOX9 expression in 166 osteosarcoma tissues with clinicopathological factors or survival of patients. SOX9 expression at mRNA and protein levels were both significantly higher in osteosarcoma tissues than those in corresponding noncancerous bone tissues (both P 
ISSN:1746-1596
1746-1596
DOI:10.1186/1746-1596-8-183