Differential regulation of myeloid leukemias by the bone marrow microenvironment
Alteration of the bone marrow microenvironment by activation of the parathyroid hormone receptor attenuates chronic myelogenous leukemia (CML) but enhances acute myeloid leukemia (AML) in mouse models, suggesting that the leukemia stem-cell niches in CML and AML are distinct. Like their normal hemat...
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Veröffentlicht in: | Nature medicine 2013-11, Vol.19 (11), p.1513-1517 |
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Zusammenfassung: | Alteration of the bone marrow microenvironment by activation of the parathyroid hormone receptor attenuates chronic myelogenous leukemia (CML) but enhances acute myeloid leukemia (AML) in mouse models, suggesting that the leukemia stem-cell niches in CML and AML are distinct.
Like their normal hematopoietic stem cell counterparts, leukemia stem cells (LSCs) in chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone marrow microenvironment (BMM)
1
and may be the cause of relapse following chemotherapy
2
. Targeting the niche is a new strategy to eliminate persistent and drug-resistant LSCs. CD44 (refs.
3
,
4
) and interleukin-6 (ref.
5
) have been implicated previously in the LSC niche. Transforming growth factor-β1 (TGF-β1) is released during bone remodeling
6
and plays a part in maintenance of CML LSCs
7
, but a role for TGF-β1 from the BMM has not been defined. Here, we show that alteration of the BMM by osteoblastic cell–specific activation of the parathyroid hormone (PTH) receptor
8
,
9
attenuates
BCR-ABL1
oncogene–induced CML-like myeloproliferative neoplasia (MPN)
10
but enhances
MLL-AF9
oncogene–induced AML
11
in mouse transplantation models, possibly through opposing effects of increased TGF-β1 on the respective LSCs. PTH treatment caused a 15-fold decrease in LSCs in wild-type mice with CML-like MPN and reduced engraftment of immune-deficient mice with primary human CML cells. These results demonstrate that LSC niches in CML and AML are distinct and suggest that modulation of the BMM by PTH may be a feasible strategy to reduce LSCs, a prerequisite for the cure of CML. |
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ISSN: | 1078-8956 1546-170X |
DOI: | 10.1038/nm.3364 |