Cytoplasmic dynein heavy chain: the servant of many masters

Highlights • The cytoplasmic dynein complex is the main retrograde motor in all eukaryotic cells. • This complex is built around a dimer of cytoplasmic dynein heavy chains (DYNC1H1). • Mouse DYNC1H1 mutants have sensory defects, but motor defects have been controversial. • Now human DYNC1H1 mutation...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2013-11, Vol.36 (11), p.641-651
Hauptverfasser:	Schiavo, Giampietro, Greensmith, Linda, Hafezparast, Majid, Fisher, Elizabeth M.C
Format:	Artikel
Sprache:	eng
Schlagworte:	amyotrophic lateral sclerosis Animals axonal transport Brain - metabolism Cramping 1 Cytoplasm Cytoplasmic Dyneins - genetics Cytoplasmic Dyneins - metabolism Eukaryotes Genetic Predisposition to Disease - genetics Humans Legs at odd angles motor neurons Mutation Mutation - genetics Nervous system neurodegeneration Neurology Neurons - metabolism Protein Multimerization Review Rodents Sprawling
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Beschreibung
Zusammenfassung:	Highlights • The cytoplasmic dynein complex is the main retrograde motor in all eukaryotic cells. • This complex is built around a dimer of cytoplasmic dynein heavy chains (DYNC1H1). • Mouse DYNC1H1 mutants have sensory defects, but motor defects have been controversial. • Now human DYNC1H1 mutations with sensory, motor, and cognitive deficits are being found. • The study of these mutations will give us new insight into DYNC1H1 function in the nervous system.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2013.08.001