Engineering New Protein-Protein Interactions on the β-Propeller Fold by Yeast Cell Surface Display
Reinventing the wheel: The β‐propeller domain folds like a wheel to provide key protein–protein interactions in the cell. Here we used high‐throughput yeast sorting to “invent” β‐propellers of new binding specificities with cellular targets.
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2013-03, Vol.14 (4), p.426-430 |
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| container_end_page | 430 |
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| container_issue | 4 |
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| container_title | Chembiochem : a European journal of chemical biology |
| container_volume | 14 |
| creator | Zhang, Keya Li, Heng Bhuripanyo, Karan Zhao, Bo Chen, Tiffany F. Zheng, Ning Yin, Jun |
| description | Reinventing the wheel: The β‐propeller domain folds like a wheel to provide key protein–protein interactions in the cell. Here we used high‐throughput yeast sorting to “invent” β‐propellers of new binding specificities with cellular targets. |
| doi_str_mv | 10.1002/cbic.201200718 |
| format | Article |
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| ispartof | Chembiochem : a European journal of chemical biology, 2013-03, Vol.14 (4), p.426-430 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals beta-propeller folds Cell Surface Display Techniques - methods Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism enzymes genetic engineering Kelch repeats Kelch-Like ECH-Associated Protein 1 Mice Models, Molecular Mutation Protein Folding Protein Interaction Maps Protein Structure, Secondary Protein Structure, Tertiary yeast-cell-surface display Yeasts - genetics Yeasts - metabolism |
| title | Engineering New Protein-Protein Interactions on the β-Propeller Fold by Yeast Cell Surface Display |
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