Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete

Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine‐derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-07, Vol.52 (30), p.7822-7824
Hauptverfasser:	Jang, Kyoung Hwa, Nam, Sang-Jip, Locke, Jeffrey B., Kauffman, Christopher A., Beatty, Deanna S., Paul, Lauren A., Fenical, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria Actinomycetes Anthrax Anthrax - drug therapy Anthrax - microbiology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Bacillus anthracis Bacillus anthracis - drug effects Bacteria Culture Derivatives Geologic Sediments - chemistry Geologic Sediments - microbiology Gram-Positive Bacteria - drug effects Microbial Sensitivity Tests Molecular Structure natural products Pathogens polyketides Polyketides - chemistry Polyketides - pharmacology Saline Stereoisomerism Structure-Activity Relationship Water Pollutants, Chemical - chemistry
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Beschreibung
Zusammenfassung:	Licensed to kill: A new antibiotic, anthracimycin (see scheme), produced by a marine‐derived actinomycete in saline culture, shows significant activity toward Bacillus anthracis, the bacterial pathogen responsible for anthrax infections. Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram‐positive bacteria, such as anthrax, but also shows activity against selected Gram‐negative bacteria.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201302749