Prenatal ontogeny as a susceptibility period for cortical GABA neuron disturbances in schizophrenia

Highlights • Cortical GABA neuron abnormalities in schizophrenia may have a prenatal origin. • Transcription regulators and other developmental factors govern GABA neuron ontogeny. • Deficits in ontogenetic transcription factors have been reported in schizophrenia. • Maternal immune activation may b...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.248, p.154-164
Hauptverfasser:	Volk, D.W, Lewis, D.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Biological and medical sciences development Disease Susceptibility - metabolism Fundamental and applied biological sciences. Psychology GABAergic Neurons - metabolism GABAergic Neurons - physiology Humans interneuron Interneurons - metabolism Interneurons - physiology Medical sciences Neurology parvalbumin prefrontal cortex Prefrontal Cortex - growth & development Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Schizophrenia - physiopathology somatostatin Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Cortical GABA neuron abnormalities in schizophrenia may have a prenatal origin. • Transcription regulators and other developmental factors govern GABA neuron ontogeny. • Deficits in ontogenetic transcription factors have been reported in schizophrenia. • Maternal immune activation may be involved in GABA neuron deficits in schizophrenia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.06.008