Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS

Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS

BACKGROUND/AIMSThe frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. g...

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Veröffentlicht in:Disease markers 2012-01, Vol.33 (6), p.309-312
Hauptverfasser: Demarco, Ana Lúcia G, Rodrigues, Maria de Lourdes V, Figueiredo, José Fernando C, Deghaide, Neifi Hassam S, de Menezes, Marcelo Bezerra, Demarco, Luís A, Fernandes, Ana Paula M, Donadi, Eduardo A
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Sprache:eng
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Zusammenfassung:BACKGROUND/AIMSThe frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied. RESULTSThe HLA-B35 was significantly increased in TRC group (p=0.0038). CONCLUSIONThe presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.
ISSN:0278-0240
1875-8630
DOI:10.3233/DMA-2012-00935