Susceptibility to toxoplasmic retinochoroiditis is associated with HLA alleles reported to be implicated with rapid progression to AIDS

The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and w...

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Veröffentlicht in:	Disease markers 2012, Vol.33 (6), p.309-312
Hauptverfasser:	Demarco, Ana Lúcia G, Rodrigues, Maria de Lourdes V, Figueiredo, José Fernando C, Deghaide, Neifi Hassam S, de Menezes, Marcelo Bezerra, Demarco, Luís A, Fernandes, Ana Paula M, Donadi, Eduardo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - genetics Adult Alleles Biomarkers - blood Case-Control Studies Chorioretinitis - blood Chorioretinitis - complications Chorioretinitis - genetics Disease Progression Female Genetic Predisposition to Disease HLA-B35 Antigen - blood Humans Male Middle Aged Other Toxoplasmosis, Ocular - blood Toxoplasmosis, Ocular - complications Toxoplasmosis, Ocular - genetics
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Zusammenfassung:	The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). 98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied. The HLA-B35 was significantly increased in TRC group (p=0.0038). The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.
ISSN:	0278-0240 1875-8630
DOI:	10.3233/DMA-2012-00935