The regulation of ApoB metabolism by insulin
Highlights • In the liver, insulin antagonizes ApoB secretion at multiple sites. • Insulin promotes ApoB clearance via multiple hepatic receptor systems. • In diabetes, ApoB secretion is increased, and ApoB clearance is decreased. • Changes in ApoB metabolism may drive cardiovascular disease in the...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2013-08, Vol.24 (8), p.391-397 |
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| container_title | Trends in endocrinology and metabolism |
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| creator | Haas, Mary E Attie, Alan D Biddinger, Sudha B |
| description | Highlights • In the liver, insulin antagonizes ApoB secretion at multiple sites. • Insulin promotes ApoB clearance via multiple hepatic receptor systems. • In diabetes, ApoB secretion is increased, and ApoB clearance is decreased. • Changes in ApoB metabolism may drive cardiovascular disease in the diabetic state. |
| doi_str_mv | 10.1016/j.tem.2013.04.001 |
| format | Article |
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| ispartof | Trends in endocrinology and metabolism, 2013-08, Vol.24 (8), p.391-397 |
| issn | 1043-2760 1879-3061 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals apolipoprotein B Apolipoproteins B - metabolism cardiovascular disease Cardiovascular Diseases - metabolism diabetes Endocrinology & Metabolism Humans insulin Insulin - metabolism Insulin Resistance - physiology Lipoproteins, VLDL - metabolism selective insulin resistance very low-density lipoprotein (VLDL) |
| title | The regulation of ApoB metabolism by insulin |
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