The regulation of ApoB metabolism by insulin

Highlights • In the liver, insulin antagonizes ApoB secretion at multiple sites. • Insulin promotes ApoB clearance via multiple hepatic receptor systems. • In diabetes, ApoB secretion is increased, and ApoB clearance is decreased. • Changes in ApoB metabolism may drive cardiovascular disease in the...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2013-08, Vol.24 (8), p.391-397
Hauptverfasser:	Haas, Mary E, Attie, Alan D, Biddinger, Sudha B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apolipoprotein B Apolipoproteins B - metabolism cardiovascular disease Cardiovascular Diseases - metabolism diabetes Endocrinology & Metabolism Humans insulin Insulin - metabolism Insulin Resistance - physiology Lipoproteins, VLDL - metabolism selective insulin resistance very low-density lipoprotein (VLDL)
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Zusammenfassung:	Highlights • In the liver, insulin antagonizes ApoB secretion at multiple sites. • Insulin promotes ApoB clearance via multiple hepatic receptor systems. • In diabetes, ApoB secretion is increased, and ApoB clearance is decreased. • Changes in ApoB metabolism may drive cardiovascular disease in the diabetic state.
ISSN:	1043-2760 1879-3061
DOI:	10.1016/j.tem.2013.04.001