Characterization and pathogenesis of anemia in glycogen storage disease type Ia and Ib

Characterization and pathogenesis of anemia in glycogen storage disease type Ia and Ib

Purpose: The aim of this study was to characterize the frequency and causes of anemia in glycogen storage disease type I. Methods: Hematologic data and iron studies were available from 202 subjects (163 with glycogen storage disease Ia and 39 with glycogen storage disease Ib). Anemia was defined as...

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Veröffentlicht in:Genetics in medicine 2012-09, Vol.14 (9), p.795-799
Hauptverfasser: Wang, David Q., Carreras, Caroline T., Fiske, Laurie M., Austin, Stephanie, Boree, Danielle, Kishnani, Priya S., Weinstein, David A.
Format: Artikel
Sprache:eng
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Adenoma - blood
Adenoma - complications
Adenoma - pathology
Adolescent
Adult
Anemia
Anemia - blood
Anemia - complications
Anemia - pathology
Biomedical and Life Sciences
Biomedicine
C-Reactive Protein - metabolism
Child
Child, Preschool
Enterocolitis - blood
Enterocolitis - complications
Enterocolitis - pathology
Female
Glycogen Storage Disease Type I - blood
Glycogen Storage Disease Type I - classification
Glycogen Storage Disease Type I - complications
Glycogen Storage Disease Type I - pathology
Hemoglobin
Hemoglobins - metabolism
Human Genetics
Humans
Infant
Iron - blood
Iron Deficiencies
Laboratory Medicine
Liver Neoplasms - blood
Liver Neoplasms - complications
Liver Neoplasms - pathology
Male
Middle Aged
original-research-article
Severity of Illness Index
Tumors
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Zusammenfassung:Purpose: The aim of this study was to characterize the frequency and causes of anemia in glycogen storage disease type I. Methods: Hematologic data and iron studies were available from 202 subjects (163 with glycogen storage disease Ia and 39 with glycogen storage disease Ib). Anemia was defined as hemoglobin concentrations less than the 5th percentile for age and gender; severe anemia was defined as presence of a hemoglobin
ISSN:1098-3600
1530-0366
DOI:10.1038/gim.2012.41