Omega 3 Fatty Acids and GPR120

Human loss-of-function gene variants in GPR120 have recently been identified that confer increased risk for obesity and metabolic syndrome. In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2012-05, Vol.15 (5), p.564-565
Hauptverfasser:	Oh, Da Young, Olefsky, Jerrold M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fatty Acids, Omega-3 - metabolism Humans Insulin Resistance - physiology Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Mice Mice, Knockout Obesity - genetics Obesity - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Human loss-of-function gene variants in GPR120 have recently been identified that confer increased risk for obesity and metabolic syndrome. In addition, GPR120 KO mice develop obesity, increased inflammation, and insulin resistance, consistent with a role for GPR120 signaling in the metabolic syndrome and diabetes mellitus.
ISSN:	1550-4131 1932-7420
DOI:	10.1016/j.cmet.2012.04.009