Roadmap for the design of drug-loaded thermoresponsive polypeptide nanoparticles

Roadmap for the design of drug-loaded thermoresponsive polypeptide nanoparticles

Chimeric polypeptides (CPs) that are derived from elastin-like polypeptides (ELPs) can self-assemble to form nanoparticles by site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone. Molecules with a distribution coefficient greater than 1.5 impart sufficient...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-12, Vol.52 (6), p.1683-1687
Hauptverfasser: McDaniel, Jonathan R., Bhattacharyya, Jayanta, Vargo, Kevin B., Hassouneh, Wafa, Hammer, Daniel A., Chilkoti, Ashutosh
Format: Artikel
Sprache:eng
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Zusammenfassung:Chimeric polypeptides (CPs) that are derived from elastin-like polypeptides (ELPs) can self-assemble to form nanoparticles by site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone. Molecules with a distribution coefficient greater than 1.5 impart sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201200899