Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment

Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment

Highlights ► Chondroitin sulfate proteoglycans in the brain matrix regulate neural plasticity. ► Extracellular metalloproteinases alter structural and synaptic plasticity. ► These changes may be due to substrate cleavage or perhaps direct action on cells.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2012-08, Vol.217, p.6-18
Hauptverfasser: Howell, M.D, Gottschall, P.E
Format: Artikel
Sprache:eng
Schlagworte:
ADAMTS
Animals
Biological and medical sciences
Brain - metabolism
chondroitin sulfate proteoglycan
Chondroitin Sulfate Proteoglycans - metabolism
extracellular matrix
Extracellular Matrix - metabolism
Fundamental and applied biological sciences. Psychology
Metalloproteases - metabolism
metalloproteinase
MMP
neural plasticity
Neurology
Neuronal Plasticity - physiology
Neurons - metabolism
Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:Highlights ► Chondroitin sulfate proteoglycans in the brain matrix regulate neural plasticity. ► Extracellular metalloproteinases alter structural and synaptic plasticity. ► These changes may be due to substrate cleavage or perhaps direct action on cells.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.05.034